Children with a variant in the SERPINE1 gene—which is found in 60% of the population—may be less responsive to mepolizumab, a drug used to treat asthma flares, according to a study published in the Journal of Allergy and Clinical Immunology.
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Study Reveals Genetic Variant May Affect Asthma Drug Response in Children
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October 1, 2026
1 min read
📰 Medical Xpress
📋 Key Takeaway
A study published in the Journal of Allergy and Clinical Immunology indicates that children with a variant in the SERPINE1 gene may have reduced responsiveness to the asthma drug mepolizumab. This genetic variant is prevalent in 60% of the population. Understanding genetic responses to medications is crucial for healthcare strategies in Iran, especially in managing asthma among children.
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