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High-fat diets disrupt immune cell function, linking obesity to inflammation in mice

Just now September 24, 2026 1 min read 📰 Medical Xpress
📋 Key Takeaway

A study reveals that high-fat diets impair the function of group 2 lymphoid cells (ILC2) in mice, which are crucial for maintaining metabolism in adipose tissue. This research highlights the link between obesity and inflammation, which could have implications for public health in Iran, where obesity rates are rising. Understanding these mechanisms may inform health policies and interventions in the country.

A group of innate immune cells, known as group 2 lymphoid cells (ILC2), are essential for maintaining a stable metabolism in adipose tissue. Obesity significantly impairs the number and function of ILC2 cells, leading to the progression of metabolism-related inflammation. Until now, it was unknown how ILC2 cells are disrupted in obesity.

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