WHO has recommended two new drugs for COVID-19, providing yet more options for treating the disease. The extent to which these medicines will save lives depends on how widely available and affordable they will be.The first drug, baricitinib, is strongly recommended for patients with severe or critical COVID-19. It is part of a class of drugs called Janus kinase (JAK) inhibitors that suppress the overstimulation of the immune system. WHO recommends that it is given with corticosteroids. Baricitinib is an oral drug, used in the treatment of rheumatoid arthritis. It provides an alternative to other arthritis drugs called Interleukin-6 receptor blockers, recommended by WHO in July 2021.WHO has also conditionally recommended the use of a monoclonal antibody drug, sotrovimab, for treating mild or moderate COVID-19 in patients who are at high risk of hospitalization. This includes patients who are older, immunocompromised, having underlying conditions like diabetes, hypertension, and obesity, and those unvaccinated.Sotrovimab is an alternative to casirivimab-imdevimab, a monoclonal antibody cocktail recommended by WHO in September 2021. Studies are ongoing on the effectiveness of monoclonal antibodies against Omicron but early laboratory studies show that sotrovimab retains its activity. The panel of experts developing the guidelines also looked at two other drugs for severe and critical COVID-19: ruxolitinib and tofacitinib. Given their uncertain effects, WHO made a conditional recommendation against their use.Today’s recommendations, forming the eighth update of WHO’s living guidelines on therapeutics and COVID-19, are based on evidence from seven trials involving over 4,000 patients with non-severe, severe, and critical COVID-19. WHO is in discussions with manufacturers to secure global supply capacity and equitable and sustainable access to the newly recommended therapeutics. The Access to COVID-19 Tools Accelerator (ACT-A) Therapeutics pillar has been engaging with pharmaceutical companies to seek comprehensive access plans for low- and middle-income countries, so that these treatments can be rapidly deployed everywhere, not just in rich countries. The ACT-A is also looking to expand licensing scope to make the products more affordable. The two newly recommended drugs - baricitinib and sotrovimab - have been invited for WHO Prequalification, which assesses the quality, efficacy and safety of priority health products to increase access in lower income countries.
WHO Recommends New COVID-19 Treatments to Improve Global Access
The WHO has recommended two new drugs, baricitinib and sotrovimab, for treating COVID-19, which could improve treatment options for patients globally. This recommendation is significant as it aims to ensure equitable access to these therapeutics, particularly for low- and middle-income countries, including Iran. The availability of these drugs may impact Iran's COVID-19 treatment strategies.
👥 Key Players
📰 What Happened
The WHO has recommended two new drugs, baricitinib and sotrovimab, for COVID-19 treatment, enhancing options for patients worldwide. These recommendations aim to improve access, especially in low- and middle-income countries.
- Baricitinib is recommended for severe COVID-19 patients, while sotrovimab is for high-risk mild or moderate cases.
- The WHO is working to ensure these drugs are affordable and accessible globally, particularly in low-income regions.
💡 Why It Matters
📚 Background
COVID-19 has led to a global health crisis, prompting the need for effective treatments. The WHO's guidelines aim to standardize and improve access to therapeutics.
🏷️ Entities Mentioned
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